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Department of Chemistry-(Aditya Editing) :: Welcome to the Department of Chemistry

Welcome to the Department of Chemistry

The mission of the Department of Chemistry is to discover scientific knowledge, communicate ideas and advance innovation. You’ll take a deeper look into the world at the molecular level. Our competitive undergraduate programs are recognized by the American Chemical Society and meet their extensive academic requirements. We also offer numerous independent research opportunities at the undergraduate and graduate level. Discover a wide range of career options in the advancing field of chemical sciences. Our programs prepare you for work in the STEM industry, academia, government, non-profit and entrepreneurship.

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Student preforming lab experiment.

Department of Chemistry :: Explore Our Programs

Explore Our Programs


Chemistry (BS)

Whether your interest is in the structure and chemical reactions in living systems, properties and reactions of organic or inorganic minerals and compounds, or how matter behaves on a molecular level, a degree in chemistry will prepare you for industry career or graduate studies. A wide variety of careers are available to chemists in industry, the government or academia. Options include, but are not limited to, chemical health and safety, toxicology, oil and petroleum, forensics, textiles, agriculture and food, polymers, environmental protection, and research.

Where It Is Offered Commerce

4 years

Foreign Language

No foreign language credits required

Delivery Face-To-Face
Total Credit Hours

124 hours

Thesis Requirements

No thesis required

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Chemistry (BS) Teaching Emphasis

There is a growing need for STEM educators. A degree in chemistry with a teacher certification will allow you to combine your passion for chemistry and the classroom. You’ll take courses in general and organic chemistry, physics, and biology. Our program offers specialized teaching courses for chemistry teachers including roles and responsibilities for STEM educators, technology-infused curriculum, and project-based learning in STEM. You’ll be required to complete a teaching residency senior year. After graduating, you’ll be certified to teach science at the secondary level (grades 7-12).

Where It Is Offered Commerce

4 years

Foreign Language

No foreign language credits required

Delivery Face-To-Face
Total Credit Hours

120-122 hours

Thesis Requirements

No thesis required

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Chemistry (MS)

You can select a thesis study and a professional master degree. If you are interested in furthering your studies in chemistry, this program will enable you to work closely with faculty members with similar research interests. Faculty research interests within the department include metal binding, surface chemistry for industrially-important catalysts, ionic liquids as catalysts in organic reactions, porphyrin-based anion receptors, bacterial nucleic acid metabolism and green chemistry approaches. The non-thesis options include a professional master degree in chemistry, professional chemical business degree, or professional chemical education degree.

Where It Is Offered Commerce

2-3 years

Foreign Language

No foreign language credits required

Delivery Face-To-Face
Total Credit Hours

Non-thesis 36, Thesis 30

Thesis Requirements

Thesis and non-thesis options available

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Department of Chemistry :: Our Facilities

Our Facilities

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Department of Chemistry :: ACS Accredited

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ACS Accredited

Our programs are approved by the American Chemical Society (ACS) and are designed to provide industry readiness. The ACS promotes excellence in chemistry education and research at institutions across the United States. ACS approved programs must meet rigorous chemistry standards and education requirements. Employers often prefer hiring students who graduated from ACS accredited programs.

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Department of Chemistry :: Featured News

News Spotlights

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Department of Chemistry :: Student Organizations and Involvement

Student Organizations

Student Affiliates of the ACS

The Student Affiliates of the American Chemical Society brings together students interested in chemical sciences and enriches their academic experience. You do not have to be a chemistry major to join. The Student Affiliates sponsor guest speakers, social events, field trips, tutoring services, revenue-generating events and various other activities throughout the academic year.

chemistry – Adelaide Bradicich -9596
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Department of Chemistry :: Research Experience for Undergraduate Students

Student Support

Research Experience for Undergraduate Students (REU)

REU is a unique research opportunity for Northeast Texas community college students interested in chemistry. Offered at A&M-Commerce, this summer-long program provides a rewarding research experience.

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Department of Chemistry :: Scholarships


As a chemistry student, you’ll have access to a wide range of scholarships specific to your degree.

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Our Research

Our chemistry faculty are excited to develop your knowledge and skills through research. Opportunities are available for both undergraduate and graduate students. We encourage you to discuss any research interests with your professors.

Regulation of Microbial Nucleic Acid Metabolism

The basic area of my research program has focused on examining the regulation of nucleic acid metabolism from an evolutionary perspective. My laboratory has been investigating the control of pyrimidine biosynthesis in pseudomonads relative to their evolving taxonomy. Pyrimidine biosynthesis is essential to prokaryotic and eukaryotic cells as it provides the substrates (UTP, CTP, dCTP and dTTP) necessary for the synthesis of RNA and DNA. There are six de novo pyrimidine biosynthetic enzymes in this pathway as can be seen below. The enzyme aspartate transcarbamoylase is the first one solely unique to this biosynthetic pathway. It has undergone much scrutiny at the level of enzyme activity since it is regulated by feedback inhibition by pyrimidine nucleotides in numerous species. My laboratory has shown that the regulation of this enzyme does differ according to the DNA homology group to which the species has been assigned. Moreover, my laboratory has demonstrated that regulation of pyrimidine biosynthetic enzyme synthesis in species of Pseudomonas is regulated by pyrimidines which changed the view that pyrimidine biosynthesis was not regulated in pseudomonads. My laboratory has also investigated the regulation of the enzyme aspartate transcarbamoylase in pseudomonads. The regulation of aspartate transcarbamoylase in pseudomonads is different than what has been observed for the Escherichia coli enzyme. It is the goal of this REU project to allow a student to learn how to process cells, prepare cells for assaying and assay the de novo pyrimidine biosynthetic enzymes. This will allow a student to understand the basic principles of biochemistry as it relates to enzymes.

Carbamoyl phosphate + L-Aspartate


Carbamoyl aspartate


Dihydroorotic acid


Orotic acid + PRPP





The Development of Synthetic Hosts for Anion Recognition and Chiral Recognition Applications and the Development of Molecular Switches

There are 3 main projects in the Starnes research group.

  1. The Development of Synthetic Hosts for Anion Recognition Applications
  2. The Development of Synthetic Hosts for Chiral Recognition Applications
  3. The Development of Molecular Switches

Project 1: The Development of Synthetic Hosts for Anion Recognition Applications.

One aspect of the Starnes research group is centered on the development of synthetic receptors for anions of environmental and biological significance. Environmentally, many anions (such as perchlorate, nitrate, nitrite, sulfate and pertechnetate) present themselves as toxic and problematic contaminants in lakes, rivers, aquifers, nuclear waste repositories etc. We aim to develop sensors and extraction agents for these anions. There are also many anions of biological importance such as DNA, RNA, proteins and peptides. The development of receptors for these analytes has diagnostic applications in the monitoring of cellular processes.

The research utilizes computational software to design the artificial receptor on a computer, analyze its conformational preferences computationally and then evaluate the receptors molecular recognition properties computationally. Receptors showing promise computationally are then synthesized in lab and studied for their anion recognition properties.

Diagram of anion recognition
Sensors and extraction agents are able to recognize specific anions.

Project 2: The Development of Synthetic Hosts for Chiral Recognition Applications.

The research group is working to modify hosts previously prepared in the research group that have been shown to function as stereoselective hosts for chiral guests in order to 1) improve on the selectivity of these types of hosts in their guest binding properties and 2) to learn more about the conformations of the hosts and host-guest complexes which will allow the group to improve on host design. One practical result from the work is that it will lead to a better understanding of biological chemistry. Chiral compounds are important, especially in biological chemistry. For example, one enantiomer of a chiral drug is useful whereas its enantiomer might be toxic or deadly. Many biological substrates and structures are chiral as well (such as proteins and what they act on or the product of an enzyme catalyzed reaction). By understanding chiral recognition better, we can understand biological chemistry better or biological recognition in general better. Understanding the structures of the hosts and their complexes will contribute to a better understanding of the requirements for selective chiral recognition. The research could also impact the design of sensors for chiral species, the development of catalysts for chiral synthesis and the separations industry (for the separation of chiral substances such as enantiomeric molecules, which would greatly impact the pharmaceutical industry since one enantiomeric of a chiral drug might be toxic and therefore must be isolated and removed from the drug mixture).

Project 3: The Development of Molecular Switches.

A molecular switch is a molecule or set of molecules that will undergo a pre-defined shift between two or more distinct states in response to a specific stimuli. A schematic illustrating the basic concept is below. There is interest in the development of molecular switches for a variety of applications such as in nanotechnology for application in molecular computers (the different states can represent the binary numerical system 0 and 1).

For this project, we will develop synthetic host compounds that contain a mechanism for a switching stimuli that arises from the stereochemistry (3D shape) of a guest which binds to the host. Depending on the absolute stereochemistry of the guest, the host will exist in one of two different conformations; if the host can exist in conformer A and conformer B, when one enantiomer of a guest binds to the porphyrin host, the host will adopt conformer A. When the opposite enantiomer of a guest binds to the host, the host will adopt conformer B. We aim to utilize 19F-NMR, Circular Dichroism (CD), and fluorescence spectroscopy to determine which conformer the host exists in (and hence determine which stereoisomer of guest is bound). If successful, we will be able to determine the absolute stereochemistry of a guest or the stereo composition of a mixture of enantiomers from the 19F-NMR, CD or fluorescence response. This will represent a major advance is chiral discrimination using spectroscopic methods. The knowledge gained from this study will contribute to a better understanding of the requirements for selective chiral recognition. This type of system could find use in the pharmaceutical industry for example for high-throughput enantiopurity determination of chiral pharmaceutical agents.

Diagram showing relationship between guest and host compounds
The stereochemistry of a guest determines the conformation of its host.

A student working on any of these projects will be trained in synthetic organic chemistry, including the synthesis, isolation, purification and identification of organic compounds. The student will use techniques such as computational chemistry, NMR, IR, circular dichroism, fluorescence and mass spectrometry to study the systems.

The Study of Transition Metal Ni, Cu, Ru, and Rh Complexes Catalyzed Asymmetric Reactions

The objective of my research projects is to develop novel chiral diamine ligands and their application for transition metal catalyzed asymmetric reactions. Due to the high demand and preference for the use of enantiopure compounds in the fields of pharmaceuticals, perfumes, food additives, etc., there has been a great interest in catalytic asymmetric synthesis as a tool for their efficient preparation. However, it has been a big challenge to obtain optically active compounds with good yields and selectivities. In the first phase of these projects, we will build on the knowledge gained from our previous work and design, synthesize and characterize various chiral diamines. In the second phase, the ability of the resulting chiral diamines as ligands for transition metals Ru, Cu, and Ni catalyzed asymmetric reactions will be carried out using selected asymmetric reactions such as Michael reaction, asymmetric transfer hydrogenation, and tandem reactions (Figure 1). Also, the extractive electrospray ionization mass spectrometry (EESI-MS) analysis will be carried out to elucidate the structural information about the reaction intermediates and the coordination chemistry of diamine ligand with transition metal in order to better understand their influence on the asymmetric controls and to assist in optimizing their structures to give more effective chiral diamines. The knowledge gained will provide fundamental insights to better understand the mechanism of asymmetric induction for a wide range of reactions.

Diagram with different chemical reactions stemming from one main reaction
Catalyzed asymmetric reactions are carried out with selected asymmetric reactions.

Design and Synthesis of Ionic Liquid-Supported (ILS) Homogeneous Organocatalysts for Asymmetric Reactions

Most of the compounds that pharmaceutical companies make have specific properties in order for them to have biological activity. Even though some of these compounds may look very similar to other compounds and may even have the same molecular formulas, they cannot be superimposed on each other and hence are really different compounds. The human body can recognize such compounds as different and one compound will be biologically active and the other one poisonous. In order to make the desired compound in large excess, specific catalysts are often used. These catalysts have to be carefully designed in order for them to give the desired product in larger quantities, compared to other similar compounds that may be produced in the reaction. An important tool that is often used to gain a rational design of such molecules is to use computer modeling. There are presently some very effective catalysts that are used to accomplish these asymmetric syntheses, but a major problem associated with their use for these asymmetric transformations is that they are not easily recovered and recycled. As a result, large amounts of catalysts are typically used, especially in industry, which poses a serious disposal problem. In this research, new categories of recyclable homogeneous organocatalysts are developed and are very effective in giving desired asymmetric compounds. These organocatalysts are unique in that they contain ionic liquid moieties, which convey a wide range of properties to the catalysts. As a result, these ionic liquid-supported (ILS) organocatalysts are tunable and their properties can be adjusted to meet a wide variety of reaction conditions. The proposed project has three aspects:

  1. REU students will gain the experience of synthesizing organocatalysts and utilize state-of-the-art instrumentation for their characterization
  2. Students will utilize newly synthesized organocatalysts to catalyze specific asymmetric reactions of organic chemistry
  3. Students will utilize the Spartan software to carry out computational modeling studies to assist in the design of effective organocatalysts for these reactions.

Chemical Education

Chemical education research examines how basic chemical principles are taught to undergraduate students. Researchers at A&M-Commerce are taking steps to improve retention rates. One method involves revising organic chemistry textbooks to help students understand complex, organic chemistry principles. Both the National Science Foundation Research Experience for Undergraduates and Noyce Grants allow for this research to happen.

Green Chemistry

Green chemistry research uses biobased processes that reduce the negative environmental effects of industrial chemical production. Researchers at A&M-Commerce study how the production of bio-oils, specialty chemicals and polysaccharides from low-value biomass could substitute for petroleum-based materials. Our goal is to develop environmentally-friendly and cost-effective bio-based processes.

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Department of Chemistry :: Meet our Faculty and Staff

Meet our Department

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Department of Chemistry :: We are Here to Help! Copy

We are here to help!

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Department of Chemistry :: Contact

Contact Us

  • P.O. Box 3011
  • Commerce, TX 75429-3011
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